Propolis Supplementation Effects on Semen Parameters, Oxidative Stress, Inflammatory Biomarkers and Reproductive Hormones in Infertile Men with Asthenozoospermia; A Randomized Clinical Trial

Authors

  • Ali Akbar Karami Department of Urology, Velayat Hospital, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
  • Fatemeh Alizadeh Metabolic Diseases Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
  • Fereshteh Gholaminejad Department of Nutrition, Faculty of Health, Qazvin University of Medical Science, Qazvin, Iran.
  • Maria Kavianpour Department of Tissue Engineering and Applied Cell Sciences, Faculty of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • Maryam Javadi Department of Nutrition, Faculty of Health, Qazvin University of Medical Science, Qazvin, Iran.
Abstract:

Background and Aims: Decreased sperm motility and increased level of oxidative stress are major causes of male infertility. This study was designed to evaluate the effect of propolis supplementation on spermatogram and reproductive hormones in asthenozoospermic men. Materials and Methods: In this randomized, double-blind controlled clinical trial, 60 asthenozoospermic men attending an infertility clinic in Velayat Hospital in Qazvin, Iran, were randomly assigned to one of intervention and placebo groups (n=30 for each group). For 10 weeks each participant in the intervention group took 1500 mg of propolis daily, while in the placebo group they received daily placebo. Sperm parameters, total antioxidant capacity, concentrations of malondialdehyde of plasma, inflammatory markers and reproductive hormones were measured at the baseline and at the end of the interventions. Results: Out of 60 who participated in this study, 29 men in the intervention group and 28 men in the placebo group completed the study. After the intervention, concentration and percentage of motile sperms as well as total antioxidant capacity of plasma significantly increased while the concentration of plasma malondialdehyde and inflammatory markers significantly decreased in the intervention group compared to the placebo group (p<0.05). Conclusions: Propolis supplementation led to increase in the concentration and motility of asthenozoospermic sperms and reduction of oxidative stress and inflammatory markers. Since increase in reactive oxygen species has been observed in abnormal sperms, oral intake of propolis may be one of the ways to deal with oxidative damage in spermatozoa of infertile men.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Effect of Carob (Ceratonia siliqua L.) oral supplementation on changes of semen parameters, oxidative stress, inflammatory biomarkers and reproductive hormones in infertile men

Background and Aim: Reduction in sperm motility is one of the main causes of male infertility. The aim of this study was to investigate the effect of Carob supplementation on sperm parameters, inflammatory factors, oxidative stress indices and sex hormones in the men with idiopathic infertility. Materials and Methods: This study was a randomized double-blind controlled clinical trial which inc...

full text

Effects of Vitamin D Supplementation on Semen Quality and Reproductive Hormones in Patients with Asthenozoospermia: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Background: Animal models and observational studies have suggested a favorable role of vitamin D in male reproduction. However, randomized clinical trials investigating the effect of vitamin D supplementation on male fertility are limited. Therefore, this study aimed to examine the effect of vitamin D supplementation on semen quality, reproductive hormones, and anthropometric measurements in vi...

full text

Effect of Ceratonia siliqua (Carob) syrup and vitamin E on sperm parameters, oxidative stress index and sex hormones in infertile men: Protocol for a randomized controlled trial

Background: Spermatogenesis is a necessary process in fertility and reproductive capacity of humans. In view of the relative high prevalence of spermatogenesis disorders in men and the failure of treatments provided in conventional medicine, new therapeutic approaches are being considered. This study will be designed to investigate the effect of Ceratonia siliqua (Carob) syrup and vitamin E on ...

full text

Effects of High-dose Selenium Supplementation on the Oxidative Stress Status and Inflammatory Markers in Critically Ill Pediatric Patients after Gastrointestinal Surgery: A Randomized Clinical Trial Protocol.

Introduction: Oxidative stress and inflammation could occur after major gastrointestinal surgeries. Selenium is a micronutrient with anti-inflammatory and antioxidant properties, which could improve the inflammatory markers in the children admitted to the intensive care unit (ICU) after gastrointestinal surgeries. Due to the lack of evidence on the potential effects of high-dos...

full text

Selenium–vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate

OBJECTIVES Infertility is an important medical and social problem that has an impact on well-being. A significant development in the last 10 years in the study of human infertility has been the discovery that oxidative sperm DNA damage has a critical role in the etiology of poor semen quality and male infertility. Selenium (Se) is an essential element for normal testicular development, spermato...

full text

Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial

Objectives: Nigella sativa is a medicinal plant that has long been used in traditional medicine for treating various conditions. Numerous animal studies provided evidences that the seed may elicit a broad anti-inflammatory/anti-oxidant activity. The aim of the present clinical trial was to evaluate anti-inflammatory and antioxidant properties of Nigella sativa oil in patients with rheumatoid ar...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 6  issue 1

pages  21- 32

publication date 2019-02

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023